The effect of phenobarbital on chlorphentermine-induced lipidosis-like alterations in renal tissue of adult and newborn rats
Identifieur interne : 003784 ( Main/Exploration ); précédent : 003783; suivant : 003785The effect of phenobarbital on chlorphentermine-induced lipidosis-like alterations in renal tissue of adult and newborn rats
Auteurs : Sam Kacew [Canada] ; Roberto Narbaitz [Canada]Source :
- Virchows Archiv B [ 0340-6075 ] ; 1981-12-01.
English descriptors
- KwdEn :
- Teeft :
- Adult rats, Alveolar foam cells, Alveolus, Arbitrary scale, Cell pathol, Chlorphentermine, Chlorphentermine phenobarbital, Electron micrograph, Electron microscopy, Health sciences, Hypertrophic macrophages, Kacew, Large number, Medullary, Medullary region, Morphologic responsiveness, Myeloid, Myeloid bodies, Narbaitz, Newborn rats, Ottawa, Pathol, Phenobarbital, Present study, Pulmonary alveoli, Rat, Renal, Renal tissue, Simultaneous administration, Svendsen, Thin sections, Tubular sections, Universityof ottawa, Virchows arch.
Abstract
Summary: Daily oral administration of 20 or 60 mg/kg chlorphentermine for 1 week produced a dose-related increase in the number of myeloid bodies in renal tissue of both adult and newborn rats. In adults myeloid bodies were present throughout the kidney while in neonates these bodies were found predominantly in the medullary region. Simultaneous administration of phenobarbital and either chlorphentermine dose resulted in a reduction in the number of myeloid bodies in kidneys of adults and newborns. Our data show that phenobarbital prevented the chlorphentermine-induced lipidosis in renal tissue and that newborns appear less sensitive than adults to the histopathologic action of anorectic on kidney.
Url:
DOI: 10.1007/BF02912055
Affiliations:
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In adults myeloid bodies were present throughout the kidney while in neonates these bodies were found predominantly in the medullary region. Simultaneous administration of phenobarbital and either chlorphentermine dose resulted in a reduction in the number of myeloid bodies in kidneys of adults and newborns. Our data show that phenobarbital prevented the chlorphentermine-induced lipidosis in renal tissue and that newborns appear less sensitive than adults to the histopathologic action of anorectic on kidney.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Kacew, Sam" sort="Kacew, Sam" uniqKey="Kacew S" first="Sam" last="Kacew">Sam Kacew</name></noRegion><name sortKey="Narbaitz, Roberto" sort="Narbaitz, Roberto" uniqKey="Narbaitz R" first="Roberto" last="Narbaitz">Roberto Narbaitz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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